MALDI-TOF Mass Spectrometry in Clinical Labs
نویسندگان
چکیده
منابع مشابه
Application of MALDI-TOF mass spectrometry in clinical diagnostic microbiology.
Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) has recently emerged as a powerful technique for identification of microorganisms, changing the workflow of well-established laboratories so that its impact on microbiological diagnostics has been unparalleled. In comparison with conventional identification methods that rely on biochemical tests and requ...
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Clinical microbiology laboratories today operate with the use of a blend of highand low-technology procedures. Despite huge steps forward in diagnostic methods based on nucleic acid amplification, clinical microbiology laboratories still rely heavily on culturing bacteria and fungi for diagnostic purposes. This process is typically done on solid (e.g., blood agar) and occasionally in liquid (i....
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Recent EU directives and regulations for quality control and authentication of food products have prompted the development of new methods for large-scale tests to ensure the protection of consumers. In view of this, an innovative method based on MALDI-TOF mass spectrometry has been developed and successfully applied to fish authentication. Highly specific mass spectrometric profiles from 25 dif...
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BACKGROUND Protein profiling with high-throughput sample preparation and MALDI-TOF MS analysis is a new potential tool for diagnosis of human diseases. However, analytical reproducibility is a significant challenge in MALDI protein profiling. This minireview summarizes studies of reproducibility of MALDI protein profiling and current approaches to improve its analytical performance. METHODS T...
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This study addressed the question of which properties in MALDI-TOF spectra are relevant to the task of identifying mass and abundance of a peptide species in human serum. Data of this type are common to biomarker studies, but significant within- and between-spectrum variabilities make quantifying biologically induced features difficult. We investigated this signal content and quantified the exi...
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ژورنال
عنوان ژورنال: Microbe Magazine
سال: 2015
ISSN: 1558-7452,1558-7460
DOI: 10.1128/microbe.10.1.2